Blar i forfatter "Evenseth, Linn Samira Mari"

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    • The GABAB Receptor - Structure, Ligand Binding and Drug Development 

      Evenseth, Linn Samira Mari; Gabrielsen, Mari; Sylte, Ingebrigt (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-07)
      The γ-aminobutyric acid (GABA) type B receptor (GABA<sub>B</sub-R) belongs to class C of the G-protein coupled receptors (GPCRs). Together with the GABA<sub>A</sub> receptor, the receptor mediates the neurotransmission of GABA, the main inhibitory neurotransmitter in the central nervous system (CNS). In recent decades, the receptor has been extensively studied with the intention being to understand ...

    • Ligand binding and dynamics of the GABAB receptor Venus flytrap domain 

      Evenseth, Linn Samira Mari (Doctoral thesis; Doktorgradsavhandling, 2019-11-15)
      <p>The gamma-amino-butyric-acid (GABA) is the main inhibitory neurotransmitter in the central nervous system (CNS) and exerts its physiological role by binding to the ionotropic GABA<sub>A</sub> and GABA<sub>C</sub> receptors and the metabotropic GABA<sub>B</sub> receptor (GABA<sub>B</sub>-R). The GABA<sub>B</sub>-R is an obligate heterodimer that belongs to class C of guanine-binding proteins ...